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  改性果膠成分的生物學(xué)活性

 《活性糖類(lèi)與膳食纖維》 2013，（1） 21－37

摘要

本文討論了果膠的結(jié)構(gòu)，改性工藝對(duì)于制備改性果膠的影響以及改性果膠的生物學(xué)活性。研究表明，果膠片段選擇性結(jié)合促轉(zhuǎn)移調(diào)節(jié)蛋白半乳糖凝結(jié)素-3（GAL-3），這種結(jié)合能顯著預(yù)防和降低癌癥發(fā)生。文章對(duì)于口服果膠在機(jī)體內(nèi)可能的吸收和運(yùn)輸模式進(jìn)行了思考，討論了與果膠活性類(lèi)似的膳食性碳水化合物如β-葡聚糖在體內(nèi)的吸收機(jī)理，這些物質(zhì)通常具有免疫調(diào)節(jié)和抗癌活性。文中最后討論了其他膳食性碳水化合物作為GAL-3抑制劑， GAL-3和其他半乳糖凝集素在細(xì)胞和組織穩(wěn)定中的起到的作用。這些結(jié)果表明，果膠產(chǎn)品能有效抑制各類(lèi)慢性疾病。

The bioactivity of modified pectin fragments 

Victor J. Morrisn, Nigel J. Belshaw, Keith W. Waldron, Ellen G. Maxwell.

Bioactive Carbohydrates and Dietary Fibre, 2013, (1) 21–37  

Abstract

This review discusses the structure of pectin, the effects of modification procedures used to prepare modified pectins, and the evidence for the bioactivity of these modified materials. It will consider the evidence for the selective binding of pectin fragments to the pro-metastatic regulatory protein galectin-3 (Gal3) and the potential effects of such binding on reducing the risks of the onset and prevention of cancer. The possible modes of uptake and transport by the body of orally consumed pectin will also be considered. In this context the uptake mechanisms for other dietary carbohydrates that show immunomodulating and anti-cancer properties, such as theb-glucans, will be discussed in terms of possible analogous behaviour for pectin. Finally the article will also consider other dietary carbohydrates that might provide a source of inhibitors for Gal3 and the possible roles of Gal3 and other members of the galectin family in cellular and tissue homeostasis that suggest potential roles for pectin-derived components in combating a range of chronic diseases.